1379313-44-6

Basic information

• Product Name: C₁₁H₁₃ClO₂
• CAS NO: 1379313-44-6
• Molecular Weight: 212.676
• Mol File: 1379313-44-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₃ClO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₃ClO₂(1379313-44-6)
• EPA Substance Registry System: C₁₁H₁₃ClO₂(1379313-44-6)

Safety Data

• Hazardous Substances Data: 1379313-44-6(Hazardous Substances Data)

Upstream product

• 40061-54-9 2-chlorophenylacetic acid ethyl ester 
• 74-88-4 methyl iodide 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 64-17-5 ethanol 
• 2184-85-2 2-(2-chloro-phenyl)-propanoic acid 

Downstream Products

• 1394168-73-0 2-(2-chlorophenyl)-2-fluoropropanoic acid 
• 1394168-92-3 2-(2-chlorophenyl)-2-fluoropropanoic acid 
• 1394168-82-1 di(naphthalen-1-yl)methyl 2-(2-chlorophenyl)-2-fluoropropanoate 
• 1394169-02-8 ethyl 2-(2-chlorophenyl)-2-fluoropropanoate 
• 2184-85-2 2-(2-chloro-phenyl)-propanoic acid 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.