13797-63-2 Usage
General Description
2-Trifluoromethyl-3H-imidazo[4,5-b]pyridine is a chemical compound with the molecular formula C7H4F3N3. It is a heterocyclic compound that contains both imidazole and pyridine rings, and the trifluoromethyl group is attached to the 2-position of the imidazole ring. 2-TRIFLUOROMETHYL-3H-IMIDAZO[4,5-B]PYRIDINE is utilized in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules and pharmaceutical drugs. It possesses unique structural features that make it an important intermediate in the development of novel therapeutics and drug discovery. Additionally, its trifluoromethyl group imparts desirable physicochemical properties, such as increased lipophilicity and metabolic stability, which are advantageous for drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 13797-63-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,9 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13797-63:
(7*1)+(6*3)+(5*7)+(4*9)+(3*7)+(2*6)+(1*3)=132
132 % 10 = 2
So 13797-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F3N3/c8-7(9,10)6-12-4-2-1-3-11-5(4)13-6/h1-3H,(H,11,12,13)
13797-63-2Relevant articles and documents
Fe(OTf)3-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles from o-arylenediamines and hexafluoroacetylacetone
Zhou, Yanmei,Shen, Guanshuo,Sui, Yuebo,Zhou, Haifeng
, p. 3396 - 3399 (2016)
An iron-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles through condensation of o-arylenediamines and hexafluoroacetylacetone followed by intramolecular addition and C–C bond cleavage in one-pot has been developed. A series of title compounds were obtained with up to 99% yield. This method is quite practical and suitable for scalable preparation due to simple experimental procedure and readily available reagents.
Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles
René, Olivier,Souverneva, Alexandra,Magnuson, Steven R.,Fauber, Benjamin P.
supporting information, p. 201 - 204 (2013/02/22)
We report an efficient one-step route to 2-fluoroalkylbenzimidazoles and -benzothiazoles via the condensation of fluorinated carboxylic acids and aromatic diamines or aminothiophenols. Additionally, we describe the syntheses of fluoroalkyl-azabenzimidazoles, -purines, and -imidazolopyrazines. This method is high-yielding with broad scope and is operationally simple with potential application to parallel synthesis.
