1379798-21-6

Basic information

• Product Name: C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾
• Synonyms: C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾
• CAS NO: 1379798-21-6
• Molecular Weight: 451.28
• Mol File: 1379798-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾(1379798-21-6)
• EPA Substance Registry System: C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾(1379798-21-6)

Safety Data

• Hazardous Substances Data: 1379798-21-6(Hazardous Substances Data)

Upstream product

• 611-53-0 5-Iodo-2'-deoxycytidine 
• 352534-79-3 (2-fluoro-5-formylphenyl)boronic acid 
• 1379798-18-1 5-iodo-2'-deoxycytidine monophosphate 

Downstream Products

• 1379798-26-1 C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾ 
• 1379798-29-4 C₁₆H₁₈FN₃O₈P^(1-)*Na⁽¹⁺⁾ 
• 1379798-40-9 C₃₀H₄₃FN₈O₁₁P^(1-)*Na⁽¹⁺⁾ 
• 1379798-43-2 C₂₈H₄₁FN₈O₁₀P^(1-)*Na⁽¹⁺⁾ 
• 1379798-34-1 C₂₂H₃₀FN₅O₉P^(1-)*Na⁽¹⁺⁾ 
• 1379798-35-2 C₂₂H₃₀FN₅O₉P^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

Synthesis of aldehyde-linked nucleotides and DNA and their bioconjugations with lysine and peptides through reductive amination

5-(5-Formylthienyl)-, 5-(4-formylphenyl)- and 5-(2-fluoro-5-formylphenyl) cytosine 2′-deoxyribonucleoside mono- (dCRMP) and triphosphates (dCRTP) were prepared by aqueous Suzuki-Miyaura cross-coupling of 5-iodocytosine nucleotides with the corresponding formylarylboronic acids. The dCRTPs were excellent substrates for DNA polymerases and were incorporated into DNA by primer extension or PCR. Reductive aminations of the model dCRMPs with lysine or lysine-containing tripeptide were studied and optimized. In aqueous phosphate buffer (pH 6.7) the yields of the reductive aminations with tripeptide III were up to 25 %. Bioconjugation of an aldehyde-containing DNA with a lysine-containing tripeptide was achieved through reductive amination in yields of up to 90 % in aqueous phosphate buffer. Joining forces: DNA-peptide conjugation through reductive amination of aldehyde-modified DNA with lysine-containing peptides was developed (see scheme). Formylaryl-linked dCTP derivatives were prepared by cross-coupling and incorporated into DNA by polymerases. The reductive amination of aldehyde-modified nucleotides and DNA was studied and optimized. Copyright