13801-51-9

Basic information

• Product Name: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 4-Hydroxy-[1,5]naphthyridine-3-carboxylate;Ethyl 4-oxo-1h-1,5-naphthyridine-3-carboxylate
• CAS NO: 13801-51-9
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.2087
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 13801-51-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 268 °C (decomp)
• Boiling Point: 368.9 °C at 760 mmHg
• Flash Point: 176.9 °C
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.573
• PKA: 1.69±0.50(Predicted)
• CAS DataBase Reference: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(13801-51-9)
• EPA Substance Registry System: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(13801-51-9)

Safety Data

• Hazardous Substances Data: 13801-51-9(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-[1,5]naphthyridine-3-carboxylic acid ethyl ester is a chemical compound that belongs to the family of naphthyridines. It is an ester derivative of 4-hydroxy-[1,5]naphthyridine-3-carboxylic acid, which is a heterocyclic compound with potential antineoplastic and immunomodulating activities. 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER has been investigated for its potential use in the treatment of cancer and autoimmune diseases. It is considered to have significant medicinal properties and is being studied for its potential therapeutic applications.

InChI:InChI=1/C11H10N2O3/c1-2-16-11(15)7-6-13-8-4-3-5-12-9(8)10(7)14/h3-6H,2H2,1H3,(H,13,14)

Upstream product

• 14029-71-1 2-(pyridin-3-yl)aminomethylene-malonic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 462-08-8 pyridin-3-ylamine 
• 101-84-8 diphenylether 
• 92-52-4 biphenyl 

Downstream Products

• 4901-93-3 3-carboxy-4-hydroxy-1,5-naphthyridine 
• 5423-54-1 4-hydroxy-1,5-naphthyridine 
• 83067-95-2 4-chloro-1,5-naphthyridine-3-carboxylic acid ethyl ester 
• 92972-61-7 2-phenyl-pyrazolo[4,3-c] [1,5]naphthyridin-3(5H)-one 

Relevant articles and documents

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Pharmaceutical composition for promoting fracture healing, preparation method thereof and application thereof

The invention relates to the technical field of medicines and discloses a pharmaceutical composition for promoting the fracture healing. Structurally speaking, the active ingredient of the pharmaceutical composition has the following structure: (img file = 'DDA0001638481410000011. TIF' wi= '347' he= '319'/) The pharmaceutical composition is mainly used for preparing medicines for promoting fracture healing. As far as action is concern, that medicine has good therapeutic effect on osteoporotic fracture, obviously promotes fracture heal, reduces blood viscosity, and has important promoting effect on osteocyte growth.

Platinum complexes of 4-hydoxy-1,5-naphthyridines as emitting dyes

4-Hydoxy-1,5-naphthyridines (HNt) are derivatives of 8-hydroxyquinolines, yet possess a wider HOMO and LUMO band gap than the latter. The cyclometalated complex of platinum(II) with Nt exists in a square planner geometry, and has a high tendency to aggregate in condensedmedia. Such a phenomenon was verified by examining its photo-luminescence spectra in different concentrations. In a dilute solution, it exhibits a yellow phosphorescence centered at 530∑555 nm, yet red-shifted to ∑660 nm in a concentrated solution or in the solid state. This series of compounds can be used as emitting dyes in light-emitting diodes (LED). The LED devices with a configuration ITO/NPB/dye (6%) in CBP/BCP/AlQ3 or TPBI/LiF/Al displayed a yellow to red color, where NPB, CBP, BCP, AlQ3 and TPBI denote 4,4′-bis[N-(1-naphthyl), Nphenylamino] biphenyl, 4,4′-bis(carbazol-9-yl)biphenyl, 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, tris(8-hydoxyquinolinato) aluminium, and 2,2′,2′-(1,3,5-benzenetriyl)tris(1-phenyl-1H- benzimidazole), respectively. The maximal light intensity exceeds 2.6 × 104 cd/m2 with an external quantum efficiency up to 5.8%.