1380584-07-5 Usage
Description
1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate is a complex organic compound derived from the semi-synthetic taxane family, characterized by its unique molecular structure and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate is used as an active pharmaceutical ingredient for the development of novel anti-cancer drugs, specifically targeting castration-resistant prostate cancer.
Used in Research and Development:
In the field of medicinal chemistry, this compound serves as a valuable research tool for understanding the structure-activity relationships of taxane-based drugs and their potential applications in cancer treatment. It can be used to develop new drug candidates with improved efficacy and reduced side effects.
Used in Drug Synthesis:
As a derivative of Cabazitaxel, this compound can be utilized in the synthesis of new semi-synthetic taxanes with enhanced antitumor properties. Its unique structure may provide insights into the design of more effective cancer therapeutics.
Used in Quality Control and Impurity Profiling:
In the manufacturing process of Cabazitaxel, this compound may be identified as an impurity. It is essential to monitor and control the levels of such impurities to ensure the safety and efficacy of the final drug product. 1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate can be used as a reference material for developing and validating analytical methods for impurity testing.
Check Digit Verification of cas no
The CAS Registry Mumber 1380584-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,5,8 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1380584-07:
(9*1)+(8*3)+(7*8)+(6*0)+(5*5)+(4*8)+(3*4)+(2*0)+(1*7)=165
165 % 10 = 5
So 1380584-07-5 is a valid CAS Registry Number.
1380584-07-5Relevant articles and documents
AMORPHOUS CABAZITAXEL
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Page/Page column 14, (2014/02/16)
The present invention is directed to an amorphous form of cabazitaxel, which can be prepared by dissolving a solid form of cabazitaxel in an organic solvent, and removing the organic solvent to dryness. The amorphous form of cabazitaxel is characterized by DSC as in FIG. 1 and/or X-ray powder diffraction pattern as in FIG. 2.
STABLE PHARMACEUTICAL FORMULATION OF CABAZITAXEL
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Page/Page column 10; 11, (2014/03/22)
The present invention relates to a stable liquid cabazitaxel formulation in an enclosed container. The enclosed container comprises a liquid phase and an gaseous phase, wherein the liquid phase comprises cabazitaxel, polysorbate 80, ethanol, and one or more pH adjusters to maintain pH about 2.8-6.0, and the gaseous phase is saturated with CO2. The present invention is also directed to a process for preparing the enclosed liquid pharmaceutical composition container.
SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF
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, (2012/11/06)
The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
