1380723-58-9

Basic information

• Product Name: C₁₆H₁₉N₃O₃S
• Synonyms: C₁₆H₁₉N₃O₃S
• CAS NO: 1380723-58-9
• Molecular Weight: 333.411
• Mol File: 1380723-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₉N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₉N₃O₃S(1380723-58-9)
• EPA Substance Registry System: C₁₆H₁₉N₃O₃S(1380723-58-9)

Safety Data

• Hazardous Substances Data: 1380723-58-9(Hazardous Substances Data)

Upstream product

• 92670-29-6 N-(3-pyridyl)morpholine 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: A potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines

The aryne [3 + 2] cycloaddition process with pyridinium imides breaks the aromaticity of the pyridine ring. By equipping the imide nitrogen with a sulfonyl group, the intermediate readily eliminates a sulfinate anion to restore the aromaticity, leading to the formation of pyrido[1,2-b]indazoles. The scope and limitation of this reaction are discussed. As an extension of this chemistry, N-tosylisoquinolinium imides, generated in situ from N′-(2-alkynylbenzylidene)-tosylhydrazides via an AgOTf-catalyzed 6-endo-dig electrophilic cyclization, readily undergo aryne [3 + 2] cycloaddition to afford indazolo[3,2-a]-isoquinolines in the same pot, offering a highly efficient route to these potential anticancer agents.