1381782-04-2

Basic information

• Product Name: 2-(chloroselenyl)-5-fluorobenzoyl chloride
• Synonyms: 2-(chloroselenyl)-5-fluorobenzoyl chloride
• CAS NO: 1381782-04-2
• Molecular Weight: 271.965
• Mol File: 1381782-04-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(chloroselenyl)-5-fluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloroselenyl)-5-fluorobenzoyl chloride(1381782-04-2)
• EPA Substance Registry System: 2-(chloroselenyl)-5-fluorobenzoyl chloride(1381782-04-2)

Safety Data

• Hazardous Substances Data: 1381782-04-2(Hazardous Substances Data)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 

Relevant articles and documents

Synthesis and antiproliferative evaluation of novel steroid-benzisoselenazolone hybrids

The two different types of steroidal benzisoselenazolone hybrids were synthesized by incorporating benzisoselenazolone scaffold into dehydroepiandrosterone and B-norcholesterol. The antiproliferative activity of the synthesized compounds against some carcinoma cell lines were investigated. The results showed that some of these compounds have better inhibitory activity than abiraterone on the proliferation of tumor cells associated with human growth hormone, and have less cytotoxicity on normal human cells. In particular, the IC50 values of the compound 8a and 8f are 5.4 and 6.5 μmol/L against human ovarian carcinoma (SKOV3) cell line, and possess SI values of 13.9 and 10.5, respectively. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.

Synthesis and applications of benzisoselenazolone modified nitrosourea compound

The present invention relates to a benzisoselenazolone modified nitrosourea compound and applications thereof, wherein the benzisoselenazolone modified nitrosourea compound is represented by a general formula I, has excellent antitumor activity, and can be widely used for preparing antitumor drugs. The general formula I is defined in the specification.

Benzisoselenazolone compound metabolite and synthesis method and application thereof

The invention provides a benzisoselenazolone derivative and pharmacologically acceptable salt thereof (please see the formula I in the specification). R1 and R2 are identical or different, and independently are hydrogen, halogen (such as F and Cl), cyano, nitryl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthiol, N(C1-C6 alkyl)2, NH(C1-C6 alkyl), COOH and SO3H. The invention further provides a medicinal composition containing the compound and application of the composition in preparation of antineoplastic drugs.