1381993-34-5

Basic information

• Product Name: (E)-1-(4-methylbenzylidene)-6-methoxy-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 1381993-34-5
• Molecular Weight: 278.351
• Mol File: 1381993-34-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-methylbenzylidene)-6-methoxy-3,4-dihydronaphthalen-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-methylbenzylidene)-6-methoxy-3,4-dihydronaphthalen-2(1H)-one(1381993-34-5)
• EPA Substance Registry System: (E)-1-(4-methylbenzylidene)-6-methoxy-3,4-dihydronaphthalen-2(1H)-one(1381993-34-5)

Safety Data

• Hazardous Substances Data: 1381993-34-5(Hazardous Substances Data)

Upstream product

• 5486-55-5 2,6-dimethoxylnaphthalene 

Relevant articles and documents

Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen- 2-one as a new class of microtubule-targeting agents

A series of 1-benzylidene-3,4-dihydronaphthalen-2-one derivatives were designed and synthesized, and their biological activities in vitro and in vivo were evaluated. The results showed a number of the title compounds exhibiting potent nanomolar activity in several human cancer cell lines. Of these, compound 22b showed the strongest inhibitory activity against human CEM, MDA-MBA-435, and K562 cells (IC50 = 1 nM), displayed in vitro inhibition of tubulin polymerization (IC50 = 3.93 μM), and significantly induced cell cycle arrest in G2/M phase. In addition, compound 22b could inhibit the tumor growth in colon nude mouse xenograft tumor model significantly and seemed safer than CA-4 when achieving a similar tumor suppression. This study provided a new molecular scaffold for the further development of antitumor agents that target tubulin.