1383026-37-6

Basic information

• Product Name: [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester
• Synonyms: [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester
• CAS NO: 1383026-37-6
• Molecular Weight: 467.519
• Mol File: 1383026-37-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester(1383026-37-6)
• EPA Substance Registry System: [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester(1383026-37-6)

Safety Data

• Hazardous Substances Data: 1383026-37-6(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 128779-47-5 (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 

Downstream Products

• 1012341-54-6 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 1562404-94-7 (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid benzyl ester 
• 1562404-70-9 (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid 
• 1038925-08-4 (3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 1038925-09-5 (3S,5R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 1394049-99-0 (2S,4R)-5-biphenyl-4-yl-4-[(3-hydroxyisoxazole-5-carbonyl)amino]-2-hydroxymethyl-2-methylpentanoic acid 

Relevant articles and documents

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NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

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