1383437-54-4

Basic information

• Product Name: N-benzyl-N'-(2-hydroxyphenyl)-N-methylformamidine
• Synonyms: N-benzyl-N'-(2-hydroxyphenyl)-N-methylformamidine
• CAS NO: 1383437-54-4
• Molecular Weight: 240.305
• Mol File: 1383437-54-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-benzyl-N'-(2-hydroxyphenyl)-N-methylformamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N'-(2-hydroxyphenyl)-N-methylformamidine(1383437-54-4)
• EPA Substance Registry System: N-benzyl-N'-(2-hydroxyphenyl)-N-methylformamidine(1383437-54-4)

Safety Data

• Hazardous Substances Data: 1383437-54-4(Hazardous Substances Data)

Upstream product

• 273-53-0 benzoxazole 
• 103-67-3 benzyl-methyl-amine 

Relevant articles and documents

Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6- tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant

No transition metals are necessary to convert benzoxazoles and 1,3,4-oxadiazoles into the corresponding pharmacologically interesting 2-aminated heterocycles by formal direct C(2)-amination using tetramethylpiperidine-N-oxoammonium tetrafluoroborate (TEMPO+BF 4-) as an oxidant (see scheme; TEMP=2,2,6,6- tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

Metal-free synthesis of 2-aminobenzoxazoles using hypervalent iodine reagent

A facile, simple, mild, and metal-free protocol for the synthesis of 2-aminobenzoxazoles has been developed via C-H bond amination of benzoxazoles with amines through a ring-opening and subsequent ring-closure approach. The reaction was performed in two steps wherein nucleophilic addition of amines across benzoxazoles takes place in the absence of any reagent or catalyst under solvent-free condition, followed by oxidative ring closure using 2-iodoxybenzoic acid as a hypervalent iodine reagent. Various cyclic, acyclic, and functionalized aliphatic amines were well tolerated under optimized reaction conditions and provided good to excellent yield of respective 2-aminobenzoxazoles.