1383531-32-5

Basic information

• Product Name: TK₄₅₄₇-070E
• Synonyms: TK₄₅₄₇-070E
• CAS NO: 1383531-32-5
• Molecular Weight: 507.493
• Mol File: 1383531-32-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: TK₄₅₄₇-070E(CAS DataBase Reference)
• NIST Chemistry Reference: TK₄₅₄₇-070E(1383531-32-5)
• EPA Substance Registry System: TK₄₅₄₇-070E(1383531-32-5)

Safety Data

• Hazardous Substances Data: 1383531-32-5(Hazardous Substances Data)

Upstream product

• 318280-95-4 1-[N-methyl-N-(phenyl)aminocarbonylmethyl]piperazine 
• 1344087-73-5 2‐(methylthio)‐8‐nitro‐6‐(trifluoromethyl)‐1,3‐ benzothiazin‐4‐one 
• 87033-30-5 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl chloride 
• 22227-59-4 2-chloro-3-nitro-5-(trifluoromethyl)benzoic acid 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 
• 98-56-6 4-chlorobenzotrifluoride 

Relevant articles and documents

Benzothiazinone compounds and their use as anti-tuberculosis agents

Novel benzothiazinone derivatives of formula (I) or a pharmaceutically acceptable salt or solvate thereof have been found to be effective against Mycobacterium tuberculosis strains and may thus be useful in the treatment of tuberculosis

Identification of antitubercular benzothiazinone compounds by ligand-based design

1,3-Benzothiazin-4-ones (BTZs) are a novel class of TB drug candidates with potent activity against M. tuberculosis. An in silico ligand-based model based on structure-activity data from 170 BTZ compounds was used to design a new series. Compounds were tested against a panel of mycobacterial strains and were profiled for cytotoxicity, stability, and antiproliferative effects. Several of the compounds showed improved activity against MDR-TB while retaining low toxicity with higher microsomal, metabolic, and plasma stability.