138460-07-8

Basic information

• Product Name: 3,5-Diiodo-4-hydroxyphenylpropionic acid
• Synonyms: 3,5-Diiodo-4-hydroxyphenylpropionic acid
• CAS NO: 138460-07-8
• Molecular Weight: 417.97
• Mol File: 138460-07-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Diiodo-4-hydroxyphenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Diiodo-4-hydroxyphenylpropionic acid(138460-07-8)
• EPA Substance Registry System: 3,5-Diiodo-4-hydroxyphenylpropionic acid(138460-07-8)

Safety Data

• Hazardous Substances Data: 138460-07-8(Hazardous Substances Data)

Upstream product

• 938-96-5 2-(4-Hydroxy-phenyl)-propionic acid 

Downstream Products

• 138460-11-4 (+)-α-methyl-3,5,3'-triiodothyroacetic acid 
• 138460-12-5 α-methyl-3,5,3'-triiodothyroacetic acid 
• 138460-09-0 ethyl 4-(4'-methoxyphenoxy)-3,5-diiodo-α-methylphenylacetate 
• 138460-10-3 4-(4'-hydroxyphenoxy)-3,5-diiodo-α-methylphenylacetic acid 
• 138460-08-9 ethyl 4-hydroxy-3,5-diiodo-α-methylphenylacetate 

Relevant articles and documents

α-Methylated Analogues of Triiodothyroalkanoic Acids: Synthesis and Biological Activity

Three novel thyroid hormone analogues: α-methyl-3,5,3'-triiodothyroacetic acid, α-methyl-3,5,3'-triiodothyropropionic acid and α-methyl-3,5,3',5'-tetraiodothyropropionic acid were synthesized.The hepatic thyroid receptor affinity of these analogues was compared to that other available thyroid analogues.The ability of these compounds to increase the activity of two hepatic enzymes and to lower blood cholesterol was compared to that of L-triiodothyronine. α-Methyl-3,5,3'-triiodothyroacetic acid was shown to have less nuclear binding affinity, less enzyme inducing ability, but more blood cholesterol lowering ability than triiodothyroacetic acid. α-Methyl-3,5,3',5'-tetraiodothyropropionic acid showed less nuclear binding affinity and less enzyme-inducing activity than α-methyl-3,5,3'-triiodothyropropionic acid.