1384974-25-7Relevant articles and documents
Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery
Evans, Cameron W.,Latter, Melissa J.,Ho, Diwei,Peerzade, Saquib Ahmed M. A.,Clemons, Tristan D.,Fitzgerald, Melinda,Dunlop, Sarah A.,Iyer, K. Swaminathan
, p. 1457 - 1462 (2012)
We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml-1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.