1384985-48-1

Basic information

• Product Name: 2-amino-6-ethoxynicotinonitrile
• Synonyms: 2-amino-6-ethoxynicotinonitrile
• CAS NO: 1384985-48-1
• Molecular Weight: 163.179
• Mol File: 1384985-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-6-ethoxynicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-ethoxynicotinonitrile(1384985-48-1)
• EPA Substance Registry System: 2-amino-6-ethoxynicotinonitrile(1384985-48-1)

Safety Data

• Hazardous Substances Data: 1384985-48-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 52471-07-5 2-amino-6-chloro-3-cyanopyridine 

Relevant articles and documents

Synthesis and properties of 5-cyano-substituted nucleoside analog with a donor-donor-acceptor hydrogen-bonding pattern

6-Aminopyridin-2-ones form Watson-Crick pairs with complementary purine analogues to add a third nucleobase pair to DNA and RNA, if an electron-withdrawing group at position 5 slows oxidation and epimerization. In previous work with a nucleoside analogue trivially named dZ, the electron withdrawing unit was a nitro group. Here, we describe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group, including its synthesis, pKa, rates of acid-catalyzed epimerization, and enzymatic incorporation.