138536-04-6

Basic information

• Product Name: (3R,4S,5S)-5-Hydroxy-2-methyl-3-phenyl-5-trifluoromethyl-isoxazolidine-4-carboxylic acid ethyl ester
• CAS NO: 138536-04-6
• Molecular Weight: 319.281
• Mol File: 138536-04-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3R,4S,5S)-5-Hydroxy-2-methyl-3-phenyl-5-trifluoromethyl-isoxazolidine-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S,5S)-5-Hydroxy-2-methyl-3-phenyl-5-trifluoromethyl-isoxazolidine-4-carboxylic acid ethyl ester(138536-04-6)
• EPA Substance Registry System: (3R,4S,5S)-5-Hydroxy-2-methyl-3-phenyl-5-trifluoromethyl-isoxazolidine-4-carboxylic acid ethyl ester(138536-04-6)

Safety Data

• Hazardous Substances Data: 138536-04-6(Hazardous Substances Data)

Upstream product

• 3376-23-6 N-methyl-α-phenylnitrone 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 136430-49-4 (Z)-4,4,4-Trifluoro-3-trimethylsilanyloxy-but-2-enoic acid ethyl ester 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 138536-07-9 (3S,4R,5S)-2-Methyl-3-phenyl-5-trifluoromethyl-5-trimethylsilanyloxy-isoxazolidine-4-carboxylic acid ethyl ester 
• 1522-43-6 ethyl 3-oxo-4,4,4-trifluorobutanoate enol 
• 3376-23-6 N-(benzylidene)methylamine N-oxide 
• 106260-08-6 ethyl 3-trifluoromethyl-3-oxo-propionate 

Relevant articles and documents

Improvements in 1,3-dipolar cycloaddition of nitrones to fluorinated dipolarophiles under solvent-free microwave activation

1,3-Dipolar cycloadditions between ethyl trifluoroacetoacetate or α-trifluoromethylstyrene and N-(benzylidene)methylamine N-oxide were performed in the absence of solvent.Under microwave irradiation in a monomode Maxidigest Prolabo reactor, quantitative y

1,3-Dipolar Cycloaddition Between Ethyl Trifluoroacetoacetate and N-(Benzylidene)methylamine N-Oxide

The 1,3-dipolar cycloaddition between ethyl trifluoroacetoacetate and N-(benzylidene)methylamine N-oxide, performed in boiling toluene, leads regio- and stereo-selectively to an isoxazolidine, while the corresponding ethyl acetoacetate is found to be unreactive under the same conditions.On the other hand, α-trifluoromethylstyrene behaves as α-methylstyrene and affords two diastereoisomeric trifluoromethyl-substituted cycloadducts.