1386373-78-9

Basic information

• Product Name: 4-[2-amino-3-cyano-5-oxo-4-(2-methoxyphenyl)-4Hindeno-[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide
• CAS NO: 1386373-78-9
• Molecular Weight: 484.535
• Mol File: 1386373-78-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-amino-3-cyano-5-oxo-4-(2-methoxyphenyl)-4Hindeno-[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-amino-3-cyano-5-oxo-4-(2-methoxyphenyl)-4Hindeno-[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide(1386373-78-9)
• EPA Substance Registry System: 4-[2-amino-3-cyano-5-oxo-4-(2-methoxyphenyl)-4Hindeno-[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide(1386373-78-9)

Safety Data

• Hazardous Substances Data: 1386373-78-9(Hazardous Substances Data)

Upstream product

• 63-74-1 sulfanilamide 
• 1386373-69-8 4-(3-oxo-3H-inden-1-yl-amino)benzenesulfonamide 
• 135-02-4 ortho-anisaldehyde 
• 109-77-3 malononitrile 
• 2834-10-8 2-(2-methoxybenzylidene)malononitrile 
• 606-23-5 1H-indene-1,3(2H)-dione 

Relevant articles and documents

Anticancer activity of novel indenopyridine derivatives

Eighteen new 4-[2-amino-3-cyano-5-oxo-4-substitutedaryl-4H-indeno[1,2-b] pyridin-1-(5H)-yl]benzenesulfonamide derivatives 6a-q were synthesized via a reaction of aromatic aldehydes, enaminone 3 and malononitrile in one-pot reaction. Also, compounds 6a-q were obtained, via another route by reaction of enaminone 3 with arylidenemalononitriles 4a-q. The structure of the synthesized compounds was characterized by microanalysis, IR, 1H-NMR, 13C-NMR and mass spectral data. All the target compounds were subjected to in vitro anticancer activity against breast cancer cell line (MCF7). Compound 6d showed a higher potency with IC50 value (4.34 μM) than that of the Doxorubicin (5.40 μM), as the reference drug, while compound 6n with IC50 value (6.84 μM) is nearly as active as Doxorubicin. Also, compounds 6a-c, 6e, 6f, 6h and 6p exhibited a moderate activity, while compounds 3, 6g, 6i-m, 6o and 6q showed weak activity.