1386928-34-2 Usage
Description
1-(4'-Methoxy[1,1'-biphenyl]-2-yl)-piperazine Hydrochloride is a chemical compound with a unique structure that exhibits agonist properties towards the 5-HT7 receptor. It is characterized by its ability to bind to and activate the 5-HT7 receptor, which is a subtype of the serotonin receptor family. 1-(4'-Methoxy[1,1'-biphenyl]-2-yl)-piperazine Hydrochloride has been found to have potential applications in various fields due to its specific interactions with the 5-HT7 receptor.
Uses
Used in Pharmaceutical Industry:
1-(4'-Methoxy[1,1'-biphenyl]-2-yl)-piperazine Hydrochloride is used as a research compound for studying the 5-HT7 receptor's role in various physiological processes and diseases. Its agonist properties make it a valuable tool in understanding the receptor's function and potential therapeutic applications.
Used in Neuroscience Research:
In neuroscience, 1-(4'-Methoxy[1,1'-biphenyl]-2-yl)-piperazine Hydrochloride is used as a selective agonist for the 5-HT7 receptor. This allows researchers to investigate the receptor's involvement in mood regulation, cognition, and other neurological processes. The compound's ability to block 5-HT-mediated cAMP accumulation in 5-HT7-expressing HeLa cells also provides insights into the receptor's signaling pathways.
Used in Drug Development:
The compound's interaction with the 5-HT7 receptor suggests potential therapeutic applications in the treatment of various disorders, such as depression, anxiety, and schizophrenia. As a result, 1-(4'-Methoxy[1,1'-biphenyl]-2-yl)-piperazine Hydrochloride may be used as a starting point for the development of new drugs targeting the 5-HT7 receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 1386928-34-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,6,9,2 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1386928-34:
(9*1)+(8*3)+(7*8)+(6*6)+(5*9)+(4*2)+(3*8)+(2*3)+(1*4)=212
212 % 10 = 2
So 1386928-34-2 is a valid CAS Registry Number.
1386928-34-2Relevant articles and documents
Investigations on the 1-(2-biphenyl)piperazine motif: Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo
Lacivita, Enza,Patarnello, Daniela,Stroth, Nikolas,Caroli, Antonia,Niso, Mauro,Contino, Marialessandra,De Giorgio, Paola,Di Pilato, Pantaleo,Colabufo, Nicola A.,Berardi, Francesco,Perrone, Roberto,Svenningsson, Per,Hedlund, Peter B.,Leopoldo, Marcello
supporting information; experimental part, p. 6375 - 6380 (2012/10/08)
Here we report the design, synthesis, and 5-HT7 receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT7 affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT7 affinities in the nanomolar range and >100-fold selectivity over 5-HT1A and adrenergic α1 receptors. 1-[2-(4-Methoxyphenyl)phenyl] piperazine (9a) showed 5-HT7 agonist properties in a guinea pig ileum assay but blocked 5-HT-mediated cAMP accumulation in 5-HT7- expressing HeLa cells.