138730-80-0

Basic information

• Product Name: 1H-Indole-2-carboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester
• CAS NO: 138730-80-0
• Molecular Formula: C16H20N2O4
• Molecular Weight: 304.346
• Mol File: 138730-80-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester(138730-80-0)
• EPA Substance Registry System: 1H-Indole-2-carboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester(138730-80-0)

Safety Data

• Hazardous Substances Data: 138730-80-0(Hazardous Substances Data)

Usage

1H-Indole-2-carboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester

The chemical name of the compound, also known as Vilazodone.

Potential antidepressant and anxiolytic properties

The compound has the potential to alleviate symptoms of depression and anxiety.

Selective serotonin reuptake inhibitor (SSRI)

Vilazodone selectively inhibits the reuptake of serotonin, a neurotransmitter involved in mood regulation.

Partial agonist of the serotonin 5-HT1A receptor

Vilazodone also acts as a partial agonist of the 5-HT1A receptor, which is involved in mood and anxiety regulation.

Treatment of major depressive disorder and generalized anxiety disorder

Vilazodone is used to treat these mental health conditions.

Increase levels of serotonin in the brain

By inhibiting the reuptake of serotonin and acting as a partial agonist of the 5-HT1A receptor, Vilazodone increases the levels of serotonin in the brain, which helps to improve mood and reduce anxiety.

Ethyl ester form

The compound is in the form of an ethyl ester, which allows for easier absorption and distribution in the body, making it an effective treatment.

Upstream product

• 71086-99-2 ethyl 5-amino-1H-indole-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16732-57-3 5-nitro-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 138730-81-1 5-[(tert-Butyloxycarbonyl)amino]indole-2-carboxylic Acid 
• 1037795-58-6 C₃₄H₃₂BrN₃O₄ 
• 1093255-88-9 5-[bis(cyclopropylmethyl)amino]-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide 
• 1093255-87-8 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-5-(dimethylamino)-1H-indole-2-carboxamide 
• 1093255-74-3 5-(β-alanylamino)-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide 
• 1190959-60-4 1,1-dimethylethyl {3-[(2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)amino]-3-oxopropyl}carbamate 
• 1093255-69-6 5-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate 
• 1093261-06-3 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate 
• 199806-27-4 5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester 
• 199806-23-0 benzyl 5-(tert-butyloxycarbonylamino)-2-carboxylate 
• 199806-24-1 5-amino-1H-indole-2-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues

Glucuronide derivatives of CBI-bearing CC-1065 analogues have been synthesized, and their cytotoxicities tested against U937 leukemia cells. The new compounds show potent antitumor activity in vitro. Compounds 1 and 2, and their corresponding glucuronides

1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.

CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.