138772-80-2

Basic information

• Product Name: Propanedioic acid, methyl(phenylmethyl)-, bis(phenylmethyl) ester
• CAS NO: 138772-80-2
• Molecular Formula: C25H24O4
• Molecular Weight: 388.463
• Mol File: 138772-80-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, methyl(phenylmethyl)-, bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, methyl(phenylmethyl)-, bis(phenylmethyl) ester(138772-80-2)
• EPA Substance Registry System: Propanedioic acid, methyl(phenylmethyl)-, bis(phenylmethyl) ester(138772-80-2)

Safety Data

• Hazardous Substances Data: 138772-80-2(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 82794-36-3 dibenzyl methylmalonate 
• 104856-46-4 benzyl 2,3,4,5,6-pentafluorobenzoate 
• 95929-64-9 benzylmethylpropanedioic acid dimethyl ester 

Relevant articles and documents

Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile. We have achieved the nickel-catalyzed benzylic substitution of benzyl esters with malonates as a soft carbon nucleophile. Primary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates as well as a wide variety of malonate derivatives were well tolerated in the nickel-catalyzed reaction, providing the corresponding alkylation products in 46-86% yields (34 examples). Additionally, we propose a possible reaction mechanism that would undergo via the ??1- A nd ??3-benzylnickel intermediates.