1388051-99-7

Basic information

• Product Name: N-(4-bromophenyl)-2-phenylquinazolin-4-amine
• Synonyms: N-(4-bromophenyl)-2-phenylquinazolin-4-amine
• CAS NO: 1388051-99-7
• Molecular Weight: 376.255
• Mol File: 1388051-99-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-bromophenyl)-2-phenylquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-2-phenylquinazolin-4-amine(1388051-99-7)
• EPA Substance Registry System: N-(4-bromophenyl)-2-phenylquinazolin-4-amine(1388051-99-7)

Safety Data

• Hazardous Substances Data: 1388051-99-7(Hazardous Substances Data)

Upstream product

• 21719-91-5 N′-(4-bromophenyl)benzamidine 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 100-52-7 benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 106-40-1 4-bromo-aniline 

Relevant articles and documents

Rhodium(III)-catalyzed [4?+?2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C[sbnd]H bond activation

A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(III)-catalyzed [4 + 2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones. This reaction features excellent regioselectivity, broad substrate scope and high step economy, which would provide the reference for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.

4-Substituted-2-phenylquinazolines as inhibitors of BCRP

We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.