13883-50-6

Basic information

• Product Name: L-Alanine, N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-alanyl]-, 1,1-dimethylethyl ester
• CAS NO: 13883-50-6
• Molecular Formula: C21H31N3O6
• Molecular Weight: 421.494
• Mol File: 13883-50-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-alanyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-alanyl]-, 1,1-dimethylethyl ester(13883-50-6)
• EPA Substance Registry System: L-Alanine, N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-alanyl]-, 1,1-dimethylethyl ester(13883-50-6)

Safety Data

• Hazardous Substances Data: 13883-50-6(Hazardous Substances Data)

Upstream product

• 21691-50-9 Ala-OtBu 
• 2483-51-4 N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester 

Downstream Products

• 13585-98-3 N^α-benzyloxycarbobyl-L-alanyl-L-alanyl-L-alanine 

Relevant articles and documents

Substrate-directed lewis-acid catalysis for peptide synthesis

A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new "remote" activation of carboxyl groups under solvent-free conditions. The presented method has the following advantages: (1) the high-yielding peptide synthesis uses a tantalum catalyst for any amino acids; (2) the reaction proceeds without any racemization; (3) the new substrate-directed chemical ligation using the titanium catalyst is applicable to convergent peptide synthesis. These advantages overcome some of the unresolved problems in classical peptide synthesis.