1388625-18-0

Basic information

• Product Name: (S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide
• Synonyms: (S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide
• CAS NO: 1388625-18-0
• Molecular Weight: 464.432
• Mol File: 1388625-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide(1388625-18-0)
• EPA Substance Registry System: (S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide(1388625-18-0)

Safety Data

• Hazardous Substances Data: 1388625-18-0(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 68968-12-7 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one 
• 5856-62-2 (S)-2-aminobutan-1-ol 
• 1352076-45-9 (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one 
• 1352073-02-9 methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate 

Downstream Products

• 1352074-13-5 (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-hydroxybutan-2-yl)-3-methylpiperidin-2-one 
• 1352073-44-9 (3S,5S,6R,8S)-8-allyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-ethyl-8-methyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium trifluoromethanesulfonate 

Relevant articles and documents

An expeditious synthesis of the MDM2-p53 inhibitor AM-8553

The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps.