1388759-32-7

Basic information

• Product Name: 1-(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)-3-(o-tolylthio)propan-2-ol
• Synonyms: 1-(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)-3-(o-tolylthio)propan-2-ol
• CAS NO: 1388759-32-7
• Molecular Weight: 337.486
• Mol File: 1388759-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)-3-(o-tolylthio)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)-3-(o-tolylthio)propan-2-ol(1388759-32-7)
• EPA Substance Registry System: 1-(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)-3-(o-tolylthio)propan-2-ol(1388759-32-7)

Safety Data

• Hazardous Substances Data: 1388759-32-7(Hazardous Substances Data)

Upstream product

• 2047-91-8 2,3-dihydro-1H-cyclopentindole 
• 1388758-36-8 4-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydrocyclopenta[b]indole 
• 137-06-4 2-thiocresol 

Relevant articles and documents

Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors

A library of 1,3-disubstituted 2-propanols was synthesized and evaluated as low molecular weight probes for β-secretase inhibition. By screening a library of 121 1,3-disubstituted 2-propanol derivatives, we identified few compounds inhibiting the enzyme at low micromolar concentrations. The initial hits were optimized to yield a potent BACE-1 inhibitor exhibiting an IC 50 constant in the nanomolar range. Exploration of the pharmacological properties revealed that these small molecular inhibitors possessed a high selectivity over cathepsin D and desirable physicochemical properties beneficial to cross the blood-brain barrier.