1388814-42-3Relevant articles and documents
2,3,4,5-Tetrakis(3′,4′-dihydroxylphenyl)thiophene: A new matrix for the selective analysis of low molecular weight amines and direct determination of creatinine in urine by MALDI-TOF MS
Chen, Suming,Chen, Li,Wang, Jianing,Hou, Jian,He, Qing,Liu, Jian'An,Wang, Jiyun,Xiong, Shaoxiang,Yang, Guoqiang,Nie, Zongxiu
, p. 10291 - 10297 (2012)
Small organic matrixes are still the most commonly used ones in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) because of their advantages of high sensitivity, convenience, and cost-effectiveness. However, due to the matrix interference in the low mass region, the direct analysis of low molecular weight amines in complex surroundings with conventional organic matrixes remains a challenge. Here, a new Br?nsted-Lowry acid compound 2,3,4,5-tetrakis(3′,4′- dihydroxylphenyl)thiophene (DHPT) was designed, synthesized, and applied as a matrix for analysis of low molecular weight amines by MALDI-TOF MS. DHPT displays good selectivity in the analysis of amines without matrix-related interference and the low picomole/femtomole limit-of-detection was obtained in positive ion mode. With DHPT, the metabolites including creatinine, glycine, alloxan, allantoin, and 3-hydroxyhippuric acid in human urine were directly analyzed by MALDI-TOF MS. The identity of these metabolites was confirmed by tandem mass spectrometry. Furthermore, the urine creatinine was quantitatively determined using isotope-labeled internal standard. This DHPT-assisted LDI MS method provides a general approach for both qualitative and quantitative analysis of low molecular weight amines.
Preparation method for molecular glass photoresist containing tetraphenyl thiophene structure
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Paragraph 0034-0041, (2019/02/19)
The invention relates to a preparation method for molecular glass photoresist containing a tetraphenyl thiophene structure. The subsequent treatment process is simplified while the yield is increasedso that industrial production can be achieved. Specifica