13889-93-5 Usage
Description
S-Isopropyl chlorothioformate, with the chemical formula C4H7ClOS, is an organosulfur compound that exists as a colorless liquid with a pungent odor. It is recognized for its reactivity with various nucleophiles and serves as a crucial intermediate in the synthesis of sulfur-containing organic compounds, playing a significant role in the field of organic chemistry.
Uses
Used in Organic Synthesis:
S-Isopropyl chlorothioformate is used as a reagent for the preparation of various sulfur-containing compounds due to its ability to react with a variety of nucleophiles. This makes it a valuable component in the creation of thioesters, thioamides, and other sulfur compounds, contributing to the advancement of organic chemistry.
Used in Chemical Production:
In the chemical industry, S-Isopropyl chlorothioformate is utilized as an important intermediate, facilitating the production of a range of sulfur-containing organic compounds that are essential for various applications across different sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 13889-93-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,8 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13889-93:
(7*1)+(6*3)+(5*8)+(4*8)+(3*9)+(2*9)+(1*3)=145
145 % 10 = 5
So 13889-93-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7ClOS/c1-3(2)7-4(5)6/h3H,1-2H3
13889-93-5Relevant articles and documents
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Adkison, Kim K.,Barrett, David G.,Deaton, David N.,Gampe, Robert T.,Hassell, Anne M.,Long, Stacey T.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Payne, J. Alan,Shewchuk, Lisa M.,Wells-Knecht, Kevin J.,Willard Jr., Derril H.,Wright, Lois L.
, p. 978 - 983 (2007/10/03)
Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes. Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an ex vivo rat calvarial bone resorption model. However, based on enzyme inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and 13C NMR experiments, these semicarbazones probably function as prodrugs of aldehydes.
