138958-56-2

Basic information

• Product Name: 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol
• Synonyms: 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol
• CAS NO: 138958-56-2
• Molecular Weight: 203.241
• Mol File: 138958-56-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol(138958-56-2)
• EPA Substance Registry System: 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol(138958-56-2)

Safety Data

• Hazardous Substances Data: 138958-56-2(Hazardous Substances Data)

Upstream product

• 71502-43-7 (3-methyl-5-isoxazolyl)-1-ethanol 
• 127-66-2 2-Phenyl-3-butyn-2-ol 
• 79-24-3 Nitroethane 
• 5780-37-0 (E)-acetaldoxime 
• 55086-61-8 5-acetyl-3-methylisoxazole 

Downstream Products

• 138958-50-6 4-[(E)-2-(5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-yl)-vinyl]-benzonitrile 
• 138958-46-0 2-methyl-2-phenyl-5-[2-(2-pyridinyl)ethenyl]-3(2H)-furanone 
• 138958-48-2 2-Methyl-2-phenyl-5-((E)-2-pyridin-4-yl-vinyl)-furan-3-one 
• 138958-47-1 2-phenyl-2-methyl-5-[2-(3-pyridinyl)ethenyl]-3(2H)-furanone 
• 138958-49-3 (E)-2-methyl-2-phenyl-5-[2-(thien-3-yl)ethenyl]-3(2H)-furanone 
• 133255-53-5 2,5-dimethyl-2-phenyl-3(2H)-furanone 

Relevant articles and documents

New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity

A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.