139-44-6 Usage
Description
1,2,3-Propanetriyl tris(12-hydroxyoctadecanoate), also known as glyceryl tris-12-hydroxystearate or trihydroxystearin, is a triester of glycerol and 12-hydroxystearic acid, a hydroxy fatty acid derived from the hydrogenation of the predominant castor oil fatty acid. This hydrogenation process results in a waxy solid substance known as castor wax, which has a wide array of applications in various industries due to its unique properties.
Uses
Used in Specialty Wax Blends:
1,2,3-Propanetriyl tris(12-hydroxyoctadecanoate) is used as a component in specialty wax blends for the production of items such as crayons, lipsticks, and stick deodorants. Its waxy nature and stability contribute to the desired texture and performance of these products.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) is used as an excipient in sustained-release capsules. Its ability to control the release of active ingredients over time makes it a valuable component in the development of long-lasting medications.
Used in Cosmetic Compositions:
Trihydroxystearin is also utilized in cosmetic compositions, where it serves as an emollient, providing a smooth and moisturizing effect on the skin.
Used in Paints, Coatings, Inks, Adhesives, and Sealants:
As a thixotrophic agent, 1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) is employed in the formulation of paints, coatings, inks, adhesives, and sealants. Its ability to improve the flow and stability of these materials enhances their performance and application properties.
Hazard
Glyceryl tris-12-hydroxystearate is a triglyceride that is similar to many other fats and oils
and is the fully hydrogenated form of the predominant castor oil fatty acid. Glyceryl tris-12-
hydroxystearate is not expected to be absorbed via any route of exposure and is of low concern
for human health effects. Glyceryl tris-12-hydroxystearate is also readily degraded in the
environment. Taking into consideration all available information on glyceryl tris- 12-hydroxystearate, it
has been determined that there is a reasonable certainty that no harm to any population subgroup
will result fi-om aggregate exposure to glyceryl tris- 12-hydroxystearate when considering dietary
exposure and all other non-occupational sources of pesticide exposure for which there is reliable
information. Therefore, it is recommended that the exemptions from the requirement of a
tolerance established for residues of glyceryl tris-12-hydroxystearate idon raw agricultural
commodities can be considered reassessed as safe under section 408(q) of the FFDCA.
Health Hazard
Glyceryl tris-12-hydroxystearate is a hydrogenated form of castor oil. There is no readily
available toxicity data on glyceryl tris-12-hydroxystearate. Limited data are available on castor
oil; as part of the Joint FAOIWHO Expert Committee on Food Additives (JECFA) evaluation of
castor oil as a food additive, it was noted that while low doses of castor oil are absorbed by
humans, higher does are not absorbed and laxation is observed, consistent with its long history of
use as a laxative (JECFA, 1979). A structure activity relationship analysis of glyceryl tris-12-
hydroxystearate was conducted by the Office of Pollution Prevention and Toxics (OPPT)
Structure Activity Team. The OPPT assessment concluded that glyceryl tris-12-hydroxystearate
was poorly absorbed via all routes of exposure and is of low concern for human health effects,
with no identified health concerns (Appendix A).
Pharmacokinetics
Glyceryl tris-12-hydroxystearate is expected to be poorly absorbed by the gastrointestinal
(GI) tract (OPPT, 2004). While no pharmacokinetic data are available on glyceryl tris-12-
hydroxysterate, as an orally-administered laxative, castor oil is not absorbed in the GI tract and is
excreted unchanged in the feces. As part of its review of castor oil and derivatives as food
additives, the European Commission's Scientific Committee for Food noted that small doses of
castor oil are hydrolyzed and absorbed completely and can be stored and metabolized similar to
dietary fatty acids (SCF, 2003).
Check Digit Verification of cas no
The CAS Registry Mumber 139-44-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 139-44:
(5*1)+(4*3)+(3*9)+(2*4)+(1*4)=56
56 % 10 = 6
So 139-44-6 is a valid CAS Registry Number.
InChI:InChI=1/C57H110O9/c1-4-7-10-31-40-51(58)43-34-25-19-13-16-22-28-37-46-55(61)64-49-54(66-57(63)48-39-30-24-18-15-21-27-36-45-53(60)42-33-12-9-6-3)50-65-56(62)47-38-29-23-17-14-20-26-35-44-52(59)41-32-11-8-5-2/h51-54,58-60H,4-50H2,1-3H3
