13901-85-4Relevant articles and documents
SEVERAL NEW CEMBRANOID DITERPENES FROM THREE SOFT CORALS OF THE RED SEA
Kinamoni, Zvia,Groweiss, Amiram,Carmely, Shmuel,Kashman, Yoel,Loya, Yossi
, p. 1643 - 1648 (1983)
Eight new diterpenoids have been isolated from three soft corals, Alcyonium utinomii, Lobophytum pauciflorum and Lobophytum crassum.The compounds were shown to be: 1,3,7,10-cembratetraen-12-ol (4); 1,3,6,11-cembratetraen-8-ol (5); 1,3,7,12(20)-cembratetraen-11-ol (6a); 2,7,11-cembratetraen-4,15-diol (8); 3,7,10-cembratrien-12,15-diol (9); and the lobolide related deacetyldeepoxy lobolide (15); deepoxy lobolide (16) and deacetyl-13-hydroxy lobolide (17), by spectral data and chemical studies (mainly ozonolysis).
KRAS G12C Inhibitor and application thereof in medicine
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Paragraph 0186-0187; 0194-0195, (2021/02/24)
The present invention relates to a novel compound having KRAS G12C modulating activity. The invention also relates to a preparation method of the compound and a pharmaceutical composition containing the compound.
Ozonolysis of bicyclic 1,2-dioxines: Initial scope and mechanistic insights
Cain, Nicole M.,Tiekink, Edward R. T.,Taylor, Dennis K.
, p. 3808 - 3819 (2012/06/29)
The ozonolysis of bicyclic 1,2-dioxines was investigated using a variety of 1,4-disubstituted 1,2-dioxines along with a 1,3-dialkyl and steroidal example, with yields ranging from moderate to excellent. Two different pathways were observed upon reaction of the 1,4-disubstituted 1,2-dioxines with ozone; one pathway saw the "expected" results, that is, cleavage of the olefinic moiety with generation of 1,4-dicarbonyl 1,2-dioxines, while the other pathway revealed a previously unobserved rearrangement involving cleavage of the peroxide linkage along with loss of either CO or CO2. Several unsymmetrical ozonolyses were also performed to further investigate the origins of this rearrangement, and initial mechanistic insights into the fragmentation pathways are discussed.
Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation
Pridmore, Simon J.,Slatford, Paul A.,Taylor, James E.,Whittlesey, Michael K.,Williams, Jonathan M.J.
supporting information; experimental part, p. 8981 - 8986 (2009/12/27)
Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)3(CO)H2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions.
