139040-41-8

Basic information

• Product Name: Benzenepropanol, a-(trichloromethyl)-, (R)-
• CAS NO: 139040-41-8
• Molecular Formula: C10H11Cl3O
• Molecular Weight: 253.556
• Mol File: 139040-41-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, a-(trichloromethyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, a-(trichloromethyl)-, (R)-(139040-41-8)
• EPA Substance Registry System: Benzenepropanol, a-(trichloromethyl)-, (R)-(139040-41-8)

Safety Data

• Hazardous Substances Data: 139040-41-8(Hazardous Substances Data)

Upstream product

• 82772-38-1 α-(trichloromethyl)benzenepropanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 1719-19-3 2-Methyl-4-phenyl-3-butyn-2-ol 
• 6181-26-6 1-trichloromethyl-3-phenyl-2-propyn-1-ol 
• 139040-36-1 4-phenyl-1,1,1-trichloro-2-butanone 

Downstream Products

• 139040-47-4 (S)-2-Azido-4-phenyl-butyric acid 
• 943-73-7 D-homophenylalanine 
• 143100-56-5 methyl (S)-2-p-anisyloxy-4-phenylbutanoate 
• 129990-77-8 (2S)-2-Hydroxy-4-phenylbutyric acid methyl ester 
• 143100-55-4 (S)-2-(p-Anisyloxy)-4-phenylbutanoic acid 

Relevant articles and documents

Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor

The invention discloses application of a piperazine structure containing compound to the preparation of a histone lysine specific demethylase (LSD1) inhibitor. The structural general formula of the compound is as shown in the following descriptions (wherein, A is hydrogen, carbonyl or thiocarbonyl) or a configurational isomer and a pharmaceutical salt thereof, or is as shown in the following descriptions or a pharmaceutical salt thereof. The compound has an obvious inhibition effect on the LSD1, can be prepared into the LSD1 inhibitor, and is used for preventing and treating a disease related to the activity of the histone LSD1.

Trichloromethyl ketones: Asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

A CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF CHIRAL MONOSUBSTITUTED OXIRANES

A new catalytic enentioselective synthesis of monosubstituted oxiranes has been developed from achiral trichloromethyl ketones by (a) enentioselective carbonyl reduction, (b) selective bis-dechlorination and (c) base-induced ring closure of the resulting chlorohydrins.