13908-11-7 Usage
Description
1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA, also known as Lomustine Related Compound B, is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical agents. It is characterized by its unique chemical structure, which includes a cyclohexyl group and a chloroethyl urea moiety. 1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA plays a significant role in the development of chemotherapy drugs and potential antitumor agents.
Uses
1. Used in Pharmaceutical Synthesis:
1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA is used as a reagent for the synthesis of lomustine, a chemotherapy drug. Its role in the synthesis process is essential for the production of effective cancer treatments.
2. Used in Antitumor Agent Development:
1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA is used as a precursor in the synthesis of N-nitrosoureas and N-nitrosothiourea, which are potential antitumor agents. These compounds have shown promise in the development of new cancer therapies.
3. Used in the Chemical Industry:
In the chemical industry, 1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA is used as an intermediate for the production of various chemicals and pharmaceuticals. Its unique structure allows for further modification and synthesis of a wide range of compounds with diverse applications.
4. Used in Research and Development:
1-CYCLOHEXYL-3-(2-CHLOROETHYL)UREA is utilized in research and development for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various fields, including medicine, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 13908-11-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13908-11:
(7*1)+(6*3)+(5*9)+(4*0)+(3*8)+(2*1)+(1*1)=97
97 % 10 = 7
So 13908-11-7 is a valid CAS Registry Number.
13908-11-7Relevant articles and documents
Pettit et al.
, p. 1029,1030 (1975)
Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions
Jaman, Zinia,Sobreira, Tiago J. P.,Mufti, Ahmed,Ferreira, Christina R.,Cooks, R. Graham,Thompson, David H.
, p. 334 - 341 (2019/02/27)
Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has been synthesized using continuous flow methodology. Desorption electrospray ionization mass spectrometry (DESI-MS) was used to quickly explore a large number of reaction conditions for one of the reaction steps and guide the efficient translation of optimized conditions to continuous lomustine production. Using only four inexpensive commercially available starting materials and a total residence time of 9 min, lomustine was prepared via a linear sequence of two chemical reactions performed separately in two telescoped flow reactors. Sequential offline extraction and filtration resulted in a 63% overall yield of pure lomustine at a production rate of 110 mg/h. The primary advantages of this approach are the rapid manufacture of lomustine with two telescoped steps to avoid isolation and purification of a labile intermediate and the mild conditions used in the nitrosylation step, thereby significantly increasing the purity and yield of this active pharmaceutical ingredient.
Heterocyclic compounds. Part IX. Syntheses of N-nitrosoureas and N-nitrosothioureas as possible antitumor agents
Sahu,Dehuri,Naik,Nayak
, p. 982 - 984 (2007/10/02)
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