139080-89-0

Basic information

• Product Name: 7(3-Hydroxy-1-propyl)camptothecin
• Synonyms: 7(3-Hydroxy-1-propyl)camptothecin
• CAS NO: 139080-89-0
• Molecular Weight: 406.438
• Mol File: 139080-89-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7(3-Hydroxy-1-propyl)camptothecin(CAS DataBase Reference)
• NIST Chemistry Reference: 7(3-Hydroxy-1-propyl)camptothecin(139080-89-0)
• EPA Substance Registry System: 7(3-Hydroxy-1-propyl)camptothecin(139080-89-0)

Safety Data

• Hazardous Substances Data: 139080-89-0(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 7689-03-4 camptothecin 

Relevant articles and documents

Chemical modification of an antitumor alkaloid camptothecin: Synthesis and antitumor activity of 7-C-substituted camptothecins

A radical substitution reaction of 20(S)-camptothecin (1) with methanol furnished 7-hydroxymethylcamptothecin (2). Reaction of 1 with primary alcohols higher than methanol gave 7-alkylcamptothecins (4), of which alkyl groups were one carbon less than the alcohols used and also 7-hydroxyalkylcamptothecins (5). For the preparation of 7-alkylcamptothecin (4), aldehydes were used as a radical source and several alkylated derivatives were synthesized. 7-Acyloxymethyl derivatives (6), 7-carbaldehyde (7), iminomethyl derivatives (10), acid (11), esters (12) and amides (13) were synthesized starting from 2. 7-Ethyl- (4b) and 7-propylcamptothecin (4c), acyloxymethyl compounds 6a, 6c and ethyl ester (12b) exhibited higher antitumor activity than 1 against L1210 in mice.