13910-55-9

Basic information

• Product Name: 1,3-Propanediamine, N-(4-chlorophenyl)-
• CAS NO: 13910-55-9
• Molecular Formula: C9H13ClN2
• Molecular Weight: 184.669
• Mol File: 13910-55-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Propanediamine, N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediamine, N-(4-chlorophenyl)-(13910-55-9)
• EPA Substance Registry System: 1,3-Propanediamine, N-(4-chlorophenyl)-(13910-55-9)

Safety Data

• Hazardous Substances Data: 13910-55-9(Hazardous Substances Data)

Usage

Type of compound

Diamine derivative

Common uses

Production of polymers and plastics
Intermediate in the synthesis of pharmaceuticals and agrochemicals

Additional properties

Insecticidal properties

Application

Used in the formulation of insecticides

Safety precautions

Handle with caution, as it can be harmful if not properly managed

Upstream product

• 5003-71-4 3-bromopropylamine hydrochloride 
• 106-47-8 4-chloro-aniline 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 

Downstream Products

• 46464-75-9 3-<4-Chlor-anilino>-propylguanidin 
• 226211-58-1 N-(p-chlorophenyl)-N'-formyl-1,3-diaminopropane 
• 52289-15-3 N-benzoyl-N'-(p-chlorophenyl)-1,3-diaminopropane 
• 1207113-85-6 C₁₈H₁₅ClF₆N₂O 
• 208724-68-9 N-acetyl-N'-(p-chlorophenyl)-1,3-diaminopropane 

Relevant articles and documents

Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators

Based on the previously published pyrazolopyridine-based hit compound for which negative allosteric modulation of both CXCR3 and CXCR4 receptors was disclosed, we designed, synthesized and biologically evaluated a set of novel, not only negative, but also positive allosteric modulators with preserved pyrazolopyridine core. Compound 9e is a dual negative modulator, inhibiting G protein activity of both receptors. For CXCR4 receptor para-substituted aromatic group of compounds distinguishes between negative and positive modulation. Para-methoxy substitution leads to functional antagonism, while para-chloro triggers agonism. Additionally, we discovered that chemotaxis is not completely correlated with G protein pathways. This is the first work in which we have on a series of compounds successfully demonstrated that it is possible to produce selective as well as dual-acting modulators of chemokine receptors, which is very promising for future research in the field of discovery of selective or dual modulators of chemokine receptors.

Selective monoformylation of 1,3-diaminopropane derivatives

A general procedure for regiospecific construction of N-aryl-N'-formyl- 1,3-diaminopropanes 2 (R=H) by selective monoformylation of N-(3- aminopropyl)arylamines 1 is described. Compounds 1 are readily obtained with high yields by aminolysis of 3-bromoprop