1391075-81-2

Basic information

• Product Name: 4-(1-(2-(benzo[b]thiophen-3-yl)acetyl)-2-methyl-N-(4-(trifluoromethyl)benzyl)azetidine-2-carboxamido)butanoic acid
• CAS NO: 1391075-81-2
• Molecular Weight: 532.584
• Mol File: 1391075-81-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(1-(2-(benzo[b]thiophen-3-yl)acetyl)-2-methyl-N-(4-(trifluoromethyl)benzyl)azetidine-2-carboxamido)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-(2-(benzo[b]thiophen-3-yl)acetyl)-2-methyl-N-(4-(trifluoromethyl)benzyl)azetidine-2-carboxamido)butanoic acid(1391075-81-2)
• EPA Substance Registry System: 4-(1-(2-(benzo[b]thiophen-3-yl)acetyl)-2-methyl-N-(4-(trifluoromethyl)benzyl)azetidine-2-carboxamido)butanoic acid(1391075-81-2)

Safety Data

• Hazardous Substances Data: 1391075-81-2(Hazardous Substances Data)

Upstream product

• 1391078-83-3 1-(2-benzo[b]thiophen-3-yl-acetyl)-2-methyl-azetidine-2-carboxylic acid 
• 1391078-59-3 C₁₇H₁₉NO₃S 
• 1391075-78-7 4-[[1-(2-benzo[b]thiophen-3-yl-acetyl)-2-methyl-azetidine-2-carbonyl]-(4-trifluoromethylbenzyl)-amino]-butyric acid ethyl ester 
• 1391077-69-2 2-[benzyl-(2-chloroethyl)amino]propionic acid ethyl ester 
• 1391077-71-6 1-benzyl-2-methylazetidine-2-carboxylic acid ethyl ester 
• 1391077-73-8 2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 1131-09-5 benzo[b]thiophene-3-acetic acid 

Relevant articles and documents

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

The free fatty acid receptor 2 (FFA2/GPR43) is considered a potential target for treatment of metabolic and inflammatory diseases. Here we describe the development of the first fluorescent tracer for FFA2 intended as a tool for assessment of thermodynamic and kinetic binding parameters of unlabeled ligands. Starting with a known azetidine FFA2 antagonist, we used a carboxylic acid moiety known not to be critical for receptor interaction as attachment point for a nitrobenzoxadiazole (NBD) fluorophore. This led to the development of 4 (TUG-1609), a fluorescent tracer for FFA2 with favorable spectroscopic properties and high affinity, as determined by bioluminescence resonance energy transfer (BRET)-based saturation and kinetic binding experiments, as well as a high specific to nonspecific BRET binding signal. A BRET-based competition binding assay with 4 was also established and used to determine binding constants and kinetics of unlabeled ligands.

AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES

Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.