139132-06-2

Basic information

• Product Name: Acetic acid, cyclopropylidene-, phenylmethyl ester
• CAS NO: 139132-06-2
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol File: 139132-06-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetic acid, cyclopropylidene-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, cyclopropylidene-, phenylmethyl ester(139132-06-2)
• EPA Substance Registry System: Acetic acid, cyclopropylidene-, phenylmethyl ester(139132-06-2)

Safety Data

• Hazardous Substances Data: 139132-06-2(Hazardous Substances Data)

Upstream product

• 78385-36-1 benzyloxycarbonylmethyltriphenylphosphonium bromide 
• 13837-45-1 1-ethoxy-1-cyclopropanol 
• 15097-38-8 (carbobenzyloxymethylene)triphenylphosphorane 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 5437-45-6 Benzyl bromoacetate 
• 100-51-6 benzyl alcohol 
• 832142-14-0 2-{1-[(methylsulfonyl)oxy]cyclopropyl}acetic acid 
• 832142-17-3 1-(2,2-diethoxyethyl)cyclopropane-1-ol 
• 832142-15-1 1-(2,2-dimethoxyethyl)cyclopropan-1-ol 
• 832142-18-4 benzyl 2-(1'-mesyloxycyclopropyl)acetate 
• 5009-28-9 cyclopropanone methyl hemiacetal 

Relevant articles and documents

SUBSTITUTED PYRROLIDINES AND THEIR USE

The invention discloses compounds of Formula (I) wherein R1, R2, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Cycloaddition of Fluorenone N-Aryl Nitrones with Methylenecyclopropanes and Sequential 1,3-Rearrangement: An Entry to Synthesis of Spirofluorenylpiperidin-4-ones

A facile synthesis of various spirofluorenylpiperidin-4-ones has been achieved in good yields from fluorenone N-aryl nitrones and methylenecyclopropanes. This method involved an initial cycloaddition to form a 5-spirocyclopropane-isoxazoline, which underwent a highly selective 1,3-rearrangement to give the desired product. The stereochemistry of the spirofluorenylpiperidin-4-one could be controlled by the cycloaddition and sequential rearrangement strategy. Furthermore, the spirofluorenylpiperidin-4-ones could be not only prepared in one-pot procedure but also converted to useful scaffolds by reduction or oxidation conditions.

Cyclopropyl building blocks for organic synthesis, part 100.[?] Advanced syntheses of cyclopropylideneacetates - Versatile multifunctional building blocks for organic synthesis

A well reproducible and inexpensive preparation of the cyclopropylideneacetates 2-4 has been developed. The key intermediate 2-(1′-mesyloxycyclopropyl)acetic acid (8), produced either from methyl phenylacetate (1) or 3,3-dimethoxypropionate (5-Me) and 3,3-diethoxypropionate (5-Et) in a sequence of Kulinkovich reductive cyclopropanation, mesylation and oxidative cleavage or cleavage and oxidation, respectively, was either converted to the benzyl ester 11b, or chlorinated (brominated) via the in situ formed acid chloride. The α-chloro- 12a and α-bromo ester 12b were dehydromesylated by treatment with triethylamine to furnish methyl 2-chloro-2-cyclopropylideneacetate (3-Me) and the 2-bromo analogue 4-Me with an overall yield of 68% (65%, 68%) and 52% (49%, 51%) respectively, starting from 1 (5-Me, 5-Et). The parent benzyl cyclopropylideneacetate 2-Bn was obtained by dehydromesylation of 11b with potassium t-butoxide in t-butyl methyl ether with an overall yield of 60% (57%, 9%) from 1 (5-Me, 5-Et).