1391838-29-1Relevant articles and documents
Functionalized phosphanyl-phosphonic acids as unusual complexing units as analogues of fosmidomycin
Montel, Sonia,Midrier, Camille,Volle, Jean-Noel,Braun, Ralf,Haaf, Klaus,Willms, Lothar,Pirat, Jean-Luc,Virieux, David
experimental part, p. 3237 - 3248 (2012/07/30)
Fosmidomycin (1a) and FR-90098 are potent inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate (MEP) pathway responsible for the biosynthesis of isoprenoids. This paper describes the synthesis of four types of targets bearing a phosphanyl-phosphonic acid motif as the common core for the inhibition of DXR. In these structures, the hydroxamic acid was replaced by various chelators based on a phosphinic acid linked to different functional groups capable of forming five- or six-membered chelating rings. Copyright
