1392206-74-4

Basic information

• Product Name: (3S)-1-[2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
• Synonyms: (3S)-1-[2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
• CAS NO: 1392206-74-4
• Molecular Weight: 519.638
• Mol File: 1392206-74-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S)-1-[2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-1-[2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid(1392206-74-4)
• EPA Substance Registry System: (3S)-1-[2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid(1392206-74-4)

Safety Data

• Hazardous Substances Data: 1392206-74-4(Hazardous Substances Data)

Upstream product

• 35598-05-1 methyl 4-methoxy-2-methylbenzoate 
• 1392206-08-4 1-[1-(2-bromoethoxy)-1,1-bis(4-methoxyphenyl)methyl]-4-methoxy-2-methylbenzene 
• 1392205-95-6 1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methanol 
• 1392206-51-7 ethyl (3S)-1-{2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylate 

Relevant articles and documents

Development of an (S)-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-Aminobutyric Acid Transporter Type4

A series of GABA uptake inhibitors related to (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114], the most potent mGAT4 inhibitor known so far, were synthesized and biologically evaluated for their inhibitory potency at the four GABA uptake transporters mGAT1-4 stably expressed in HEK-293 cell lines. New analogues were developed with potencies that are similar to or slightly higher than those of current mGAT4 inhibitors, but with distinctly improved chemical stability. (S)-Nipecotic acid derivatives possessing a 2-[1-(4-methoxy-2-methylphenyl)-1,1-bis(4-methoxyphenyl)methoxy]ethyl (DDPM-859) or a 4,4,4-tris(4-methoxyphenyl)but-2-en-1-yl moiety (DDPM-1457) were found to exhibit pIC50 values of 5.78 and 5.87, respectively. Thus, as mGAT4 inhibitors, these compounds compare well with (S)-SNAP-5114 (pIC50=5.71), but are far more stable than the latter. Moreover, DDPM-859 displays a more favorable subtype selectivity for mGAT4 versus mGAT3 than does (S)-SNAP-5114.