1392498-16-6

Basic information

• Product Name: C₁₇H₁₄N₂O₄S₂
• Synonyms: C₁₇H₁₄N₂O₄S₂
• CAS NO: 1392498-16-6
• Molecular Weight: 374.441
• Mol File: 1392498-16-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₄N₂O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₄N₂O₄S₂(1392498-16-6)
• EPA Substance Registry System: C₁₇H₁₄N₂O₄S₂(1392498-16-6)

Safety Data

• Hazardous Substances Data: 1392498-16-6(Hazardous Substances Data)

Upstream product

• 6315-52-2 1,2-bis-tosyloxyethane 
• 939-69-5 2-cyano-6-hydroxybenzothiazole 
• 943-03-3 2-cyano-6-methoxybenzothiazole 

Relevant articles and documents

Efficient method for site-specific 18F-labeling of biomolecules using the rapid condensation reaction between 2-cyanobenzothiazole and cysteine

An efficient method based on a rapid condensation reaction between 2-cyanobenzothiazole (CBT) and cysteine has been developed for 18F-labeling of N-terminal cysteine-bearing peptides and proteins. An 18F-labeled dimeric cRGD ([18F]CBTRGD2) has been synthesized with an excellent radiochemical yield (92% based on radio-HPLC conversion, 80% decay-corrected, and isolated yield) and radiochemical purity (>99%) under mild conditions using 18F-CBT, and shown good in vivo tumor targeting efficiency for PET imaging. The labeling strategy was also applied to the site-specific 18F-labeling of a protein, Renilla lucifierase (RLuc8) with a cysteine residue at its N-terminus. The protein labeling was achieved with 12% of decay-corrected radiochemical yield and more than 99% radiochemical purity. This strategy should provide a general approach for efficient and site-specific 18F-labeling of various peptides and proteins for in vivo molecular imaging applications.