139264-15-6

Basic information

• Product Name: Didesmethyl Zolmitriptan
• Synonyms: 4-[3-(2-Aminoethyl)-1H-indol-5-yl]methyl-2-oxazolidinon;Didesmethyl Zolmitriptan;4-[3-(2-Aminoethyl)-1H-indol-5-yl]methyl-2-oxazolidinone;ZolMitriptan DiDesMethyl IMpurity;Didesmethyl Zolmitriptan (90%);Zolmitriptan amine impurity
• CAS NO: 139264-15-6
• Molecular Formula: C₁₄H₁₇N₃O₂
• Molecular Weight: 258.29574
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines;Aromatics;Heterocycles
• Mol File: 139264-15-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 250 °C (decomp)
• Boiling Point: 595°C at 760 mmHg
• Flash Point: 313.6°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 4E-14mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.57±0.40(Predicted)
• CAS DataBase Reference: Didesmethyl Zolmitriptan(CAS DataBase Reference)
• NIST Chemistry Reference: Didesmethyl Zolmitriptan(139264-15-6)
• EPA Substance Registry System: Didesmethyl Zolmitriptan(139264-15-6)

Safety Data

• Hazardous Substances Data: 139264-15-6(Hazardous Substances Data)

Usage

Chemical Properties

Dark Brown Solid

Uses

A metabolite of Zolmitriptan (Z639000).

InChI:InChI=1/C14H17N3O2/c15-4-3-10-7-16-13-2-1-9(6-12(10)13)5-11-8-19-14(18)17-11/h1-2,6-7,11,16H,3-5,8,15H2,(H,17,18)

Upstream product

• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 187975-62-8 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one 
• 868622-25-7 2-(2-{5-[(4S)-2-oxo-1,3-oxazolan-4-ylmethyl]-1H-3-indolyl}ethyl)-2,3,3a,7a-tetrahydro-1H-1,3-isoindoledione 
• 868622-21-3 ethyl (S)-3-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-5-[(2-oxooxazolidin-4-yl)methyl]-1H-indole-2-carboxylate 
• 139264-55-4 (S)-4-(4'-nitrobenzyl)-1,3-oxazolidin-2-one 
• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 89288-22-2 (S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 29882-07-3 4-chlorobutanal dimethyl acetal 
• 139264-57-6 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride 

Downstream Products

• 139264-17-8 zolmitriptan 

Relevant articles and documents

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.

Indolyl tetrahydropyridines for treating migraine

STR1 The present invention is concerned with compounds of formula (I), wherein n is an integer of from 0 to 3: W is a group of formula (i), (ii), or (iii), wherein R is hydrogen or C1-4 alkyl, X is --O--, --S--, --NH--, or --CH2 --, Y is oxygen or sulphur and the chiral center (*) in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions: and Z is a group of formula (iv), (v), or (vi), wherein R1 and R2 are independently selected from hydrogen and C1-4 alkyl and R3 is hydrogen or C1-4 alkyl; and their salts, solvates and physiologically functional derivatives, with processes for their preparation, with medicaments containing them and with their use as therapeutic agents, particularly in the prophylaxis and treatment of migraine.