139300-46-2Relevant articles and documents
Organophosphorus osteotropic cyclopodands.
Mollier, H.,Vincens, M.,Vidal, M.,Pasqualini, R.,Duet, M.
, p. 787 - 795 (2007/10/02)
Various phosphorus containing ligands (including phosphonic acids, phosphinic acids and phosphine oxide derivatives) have been synthesized and complexed to technetium.The species derived from benzene-1,2,4,5-tetra(methylenephosphonic) acid (BTMP) and 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetra-(methylenephosphonic) acid (TTMP) which are osteotropic vectors have demonstrated excellent tracing properties on animal tests.These tracers however were less effective upon human tests.The differences in their respective biological activities led us to investigate their physicochemical properties in solution. Key Words: organophosphorus cyclopodands / phosphonic acid / technetium / complexes / osteotropic tracers