1393083-39-0

Basic information

• Product Name: 10-{[1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-{trifluoromethyl}-10H-phenothiazine
• Synonyms: 10-{[1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-{trifluoromethyl}-10H-phenothiazine
• CAS NO: 1393083-39-0
• Molecular Weight: 472.921
• Mol File: 1393083-39-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 10-{[1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-{trifluoromethyl}-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-{[1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-{trifluoromethyl}-10H-phenothiazine(1393083-39-0)
• EPA Substance Registry System: 10-{[1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-{trifluoromethyl}-10H-phenothiazine(1393083-39-0)

Safety Data

• Hazardous Substances Data: 1393083-39-0(Hazardous Substances Data)

Upstream product

• 1045778-02-6 10-(prop-2-yn-1-yl)-2-(trifluoromethyl)-10H-phenothiazine 
• 27032-10-6 4-chlorobenzyl azide 
• 92-30-8 2-(trifluoromethyl)-10H-phenothiazine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant articles and documents

Antiproliferative phenothiazine hybrids as novel apoptosis inducers against MCF-7 breast cancer

We designed a series of novel phenothiazine-1,2,3-triazole hybrids by the molecular hybridization strategy and evaluated their antiproliferative activity against three cancer cell lines (MDA-MB-231, MDA-MB-468 and MCF-7). For the structure-activity relationships, the importance of 1,2,3-triazole and substituents on phenyl ring was explored. Among these phenothiazine-1,2,3-triazole hybrids, compound 9f showed the most potent inhibitory effect against MCF-7 cells, with an IC50 value of 0.8 μM. Importantly, compound 9f could induce apoptosis against MCF-7 cells by regulating apoptosis-related proteins (Bcl-2, Bax, Bad, Parp, and DR5). These potent phenothiazine-1,2,3-triazole hybrids as novel apoptosis inducers might be used as antitumor agents in the future.