1393112-44-1

Basic information

• Product Name: 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde
• Synonyms: 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde
• CAS NO: 1393112-44-1
• Molecular Weight: 473.891
• Mol File: 1393112-44-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde(1393112-44-1)
• EPA Substance Registry System: 5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde(1393112-44-1)

Safety Data

• Hazardous Substances Data: 1393112-44-1(Hazardous Substances Data)

Upstream product

• 179246-45-8 4-(2-fluorobenzyloxy)-3-chlorobenzenamine 
• 446-48-0 o-fluorobenzyl bromide 
• 619-08-9 2-chloro-4-nitrophenol 
• 179246-44-7 2-chloro-1-[(2-fluorobenzyl)oxy]-4-nitrobenzene 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 1393112-43-0 N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-iodoquinazoline-4-amine hydrochloride 

Downstream Products

• 1393112-45-2 N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine 

Relevant articles and documents

Methods for detecting and reducing impurities of Lapatinib and salts thereof

Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.

METHODS FOR DETECTING AND REDUCING IMPURITIES OF LAPATINIB AND SALTS THEREOF

Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.