139345-88-3

Basic information

• Product Name: (2S,3R)-trans-(4-methoxyphenyl)glycidic acid butyl ester
• Synonyms: (2S,3R)-trans-(4-methoxyphenyl)glycidic acid butyl ester
• CAS NO: 139345-88-3
• Molecular Weight: 250.295
• Mol File: 139345-88-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,3R)-trans-(4-methoxyphenyl)glycidic acid butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-trans-(4-methoxyphenyl)glycidic acid butyl ester(139345-88-3)
• EPA Substance Registry System: (2S,3R)-trans-(4-methoxyphenyl)glycidic acid butyl ester(139345-88-3)

Safety Data

• Hazardous Substances Data: 139345-88-3(Hazardous Substances Data)

Upstream product

• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 71-36-3 butan-1-ol 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 

Relevant articles and documents

A practical procedure for the large-scale preparation of methyl (2R,3S)-3-(4-methoxyphenyl) glycidate, a key intermediate for diltiazem

A practical synthesis of methyl (2R,3S)-3-(4- methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), was developed. Treatment of methyl (E)-4-methoxycinnamate 3 with chiral dioxirane, generated from chiral ketone 4, provided (-)-2 in 77% ee and 89% yield. The crude mixture of (-)-2 and 4 was efficiently separated by the use of novel and simple equipment performing a lipase-catalyzed transesterification and a continuous dissolution and crystallization to furnish the optically pure (-)-2 and recovery of 4 in 74% and 91% yield, respectively.

The enzymatic preparation of (2R,3S) phenyl glycidic acid esters

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