1393571-54-4

Basic information

• Product Name: 6-(4-((E)-3-(4-(4-fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone
• Synonyms: 6-(4-((E)-3-(4-(4-fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone
• CAS NO: 1393571-54-4
• Molecular Weight: 537.593
• Mol File: 1393571-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-((E)-3-(4-(4-fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-((E)-3-(4-(4-fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone(1393571-54-4)
• EPA Substance Registry System: 6-(4-((E)-3-(4-(4-fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone(1393571-54-4)

Safety Data

• Hazardous Substances Data: 1393571-54-4(Hazardous Substances Data)

Upstream product

• 95-55-6 2-amino-phenol 
• 1393571-49-7 (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylic acid 
• 70931-28-1 1-(4-fluorophenylmethyl)piperazine 
• 1393571-48-6 3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-carboxyaldehyde 
• 1393571-47-5 C₁₆H₁₅N₃O₂ 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 54903-61-6 6-acetyl-3-methylbenzoxazolinone 

Relevant articles and documents

Synthesis, anti-inflammatory, antiplatelet and in silico ealuations of (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole- 4-yl)acrylamides

A series of (E) -3-(3-(2,3-dihydro-3-methyl-2-oxo-3H -benzoxazole-6-yl)-1- phenyl-1H -pyrazole-4-yl)acrylamides (7a-k) were synthesized and ealuated for their in itro inhibitory actiities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized deriaties 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet actiity with selectie COX-2 inhibition. TUeBITAK.