139359-60-7

Basic information

• Product Name: (2S)-1-[(1'S)-1'-phenylethyl]-2-ethoxycarbonyl-4-methyl-4,5-didehydropiperidine
• Synonyms: (2S)-1-[(1'S)-1'-phenylethyl]-2-ethoxycarbonyl-4-methyl-4,5-didehydropiperidine
• CAS NO: 139359-60-7
• Molecular Weight: 273.375
• Mol File: 139359-60-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-1-[(1'S)-1'-phenylethyl]-2-ethoxycarbonyl-4-methyl-4,5-didehydropiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-[(1'S)-1'-phenylethyl]-2-ethoxycarbonyl-4-methyl-4,5-didehydropiperidine(139359-60-7)
• EPA Substance Registry System: (2S)-1-[(1'S)-1'-phenylethyl]-2-ethoxycarbonyl-4-methyl-4,5-didehydropiperidine(139359-60-7)

Safety Data

• Hazardous Substances Data: 139359-60-7(Hazardous Substances Data)

Upstream product

• 37662-06-9 ethyl <(S)-1-phenylethyl>iminoethanoate 
• 78-79-5 isoprene 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Relevant articles and documents

Diastereoselective synthesis of an argatroban intermediate, ethyl (2R,4R)-4-methylpipecolate, by means of a Mandyphos/rhodium complex-catalyzed hydrogenation

The synthetic antithrombotic argatroban is a dipeptide between the nonproteogenic (2R,4R)-4-methyl-2-piperidine carboxylic acid and l-arginine, in turn bonded to a methyltetrahydroquinoline sulfonyl group. An extensive screening of transition metal-based complexes with different ligands was performed in order to identify the best catalyst for the diastereoselective hydrogenation of a suitable 4,5-dehydropiperidine precursor aimed toward a synthesis of the (2R,4R)-4-methyl piperidine moiety. Copyright