1393826-54-4Relevant articles and documents
Tetracyclic spirooxindole blockers of hNaV1.7: Activity in vitro and in CFA-induced inflammatory pain model
Chowdhury, Sultan,Liu, Shifeng,Cadieux, Jay A.,Hsieh, Tom,Chafeev, Mikhail,Sun, Shaoyi,Jia, Qi,Sun, Jianyu,Wood, Mark,Langille, Jonathan,Sviridov, Serguei,Fu, Jianmin,Zhang, Zaihui,Chui, Ray,Wang, Audrey,Cheng, Xing,Zhong, Jing,Hossain, Sazzad,Khakh, Kuldip,Rajlic, Ivana,Verschoof, Henry,Kwan, Rainbow,Young, Wendy
, p. 1825 - 1836 (2013/07/26)
The structure-activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model.
