139392-85-1Relevant articles and documents
A PRACTICAL SYNTHESIS OF α-AMINOPHOSPHONIC ACIDS
Genet, J. P.,Uziel, J.,Port, M.,Touzin, A. M.,Roland, S.,et al.
, p. 77 - 80 (2007/10/02)
The preparation of diterbutyl-N (diphenylmethylene) aminomethylphosphonate 3 in four steps (42percent overall yield) from N-hydroxymethyl phthalimide 1 is described.Various α substituted α-aminophosphonic acids 5 containing functionalized unsaturated chains have been synthesized by alkylation of 3 under phase transfer catalysis with halides, Michael acceptors and palladium promoted reactions, followed by mild hydrolysis. Key words: Schiff bases of diterbutylaminomethylphosphonate; phase transfer catalysis; palladium-catalyzed allylic substitution; Michael additions.