1394043-87-8

Basic information

• Product Name: 2-(4-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate
• CAS NO: 1394043-87-8
• Molecular Weight: 381.496
• Mol File: 1394043-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate(1394043-87-8)
• EPA Substance Registry System: 2-(4-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate(1394043-87-8)

Safety Data

• Hazardous Substances Data: 1394043-87-8(Hazardous Substances Data)

Upstream product

• 134-81-6 benzil 
• 54016-70-5 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide 
• 1394043-86-7 4-ethyl-6-(2-hydroxyethyl)-5-methyl-2-phenyl-2,3-dihydro-4H-1,4-thiazin-3-one 
• 98-88-4 benzoyl chloride 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 

Relevant articles and documents

Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: Discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones

Diaryl α-diketones do not undergo polarity reversal in the presence of (benzo)thiazolium carbenes but are engaged in a novel multicomponent reaction with water to efficiently give medicinally relevant 1,4-thiazin-3-one heterocycles. Three different sets of conditions have been optimized to furnish the title compounds in fair to excellent yields depending on the electronic properties of α-diketone aromatic substituents and thiazolium or benzothiazolium substrate. A plausible reaction mechanism is also proposed based on the isolation and characterization of the postulated key intermediate and isotopic labeling experiments.