1394046-53-7

Basic information

• Product Name: (R)-2-(4-chlorobenzyl)-5-oxohexanal
• CAS NO: 1394046-53-7
• Molecular Weight: 238.714
• Mol File: 1394046-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-chlorobenzyl)-5-oxohexanal(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-chlorobenzyl)-5-oxohexanal(1394046-53-7)
• EPA Substance Registry System: (R)-2-(4-chlorobenzyl)-5-oxohexanal(1394046-53-7)

Safety Data

• Hazardous Substances Data: 1394046-53-7(Hazardous Substances Data)

Upstream product

• 1615-02-7 p-chlorocinnamic acid 
• 75677-02-0 3-(4-chlorophenyl)propionaldehyde 
• 78-94-4 methyl vinyl ketone 

Relevant articles and documents

Synthesis of optically active 4-substituted 2-cyclohexenones

Recently, Nicolaou and Baran independently synthesized optically active 4-substituted 2-cyclohexenones via an efficient LiOH-mediated intramolecular aldol condensation. Thus far, application of their cyclization approach has been limited to ketoaldehydes where the R-group is branched. It is demonstrated that the LiOH-mediated cyclization, when applied to substrates containing unbranched R-groups, results in significant erosion of optical purity. A mechanistic justification is provided, and a set of neutral, organocatalyzed conditions is identified that enables cyclization with little loss in optical purity.