1394291-05-4Relevant articles and documents
Diverted organic synthesis (DOS): Accessing a new, natural product inspired, neurotrophically active scaffold through an intramolecular Pauson-Khand reaction
Mehta, Goverdhan,Samineni, Ramesh,Srihari, Pabbaraja,Reddy, R. Gajendra,Chakravarty, Sumana
, p. 6830 - 6833,4 (2012)
Drawing inspiration from the impressive neurotrophic activity exhibited by the natural product paecilomycine A, we have designed a new natural product-like scaffold employing an intramolecular Pauson-Khand reaction. Several compounds based on the new designer scaffold exhibited promising neurotrophic activity and are worthy of further biological evaluation. Our findings also highlight the importance of a DOS strategy in creating useful therapeutical leads.