1394820-99-5Relevant articles and documents
Oral liquid containing naphthyridine compound and preparation method thereof
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Paragraph 0028; 0031, (2021/10/27)
The invention relates to the field of medicines, in particular to oral liquid containing naphthyridine compounds and a preparation method of the oral liquid. Every 100 mL of the oral liquid containing the naphthyridine compound is prepared from the following raw materials: 40 to 70 g of pharmaceutically acceptable salt of 5-((3-fluoro-4-((7-(2-hydroxy-2-methylpropyl) quinoline-4-yl) oxo) phenyl) amino)-3-(4-fluorophenyl)-1, 6-naphthyridine-4 (1H)-ketone, 5 to 10 g of stabilizer and 0.3 to 6 g of solubilizer. A pH regulator is used for regulating the pH value to 5.5-6.2; according to the oral liquid containing the naphthyridine compounds, the pH value of the oral liquid containing the naphthyridine compounds is adjusted to 5.5-6.2, and the dosage of each raw material is limited, so that the stability of the oral liquid containing the naphthyridine compounds can be remarkably improved.
Naphthyridine compound and pharmaceutical composition as well as applications thereof
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Paragraph 0116; 0117; 0122; 0123, (2017/08/02)
The invention relates to the field of biological medicines and discloses a naphthyridine compound and a pharmaceutical composition as well as applications thereof. The naphthyridine compound has a structure shown in a formula (I) or a stereisomer, a geometric isomer, a tautomer, nitric oxide, hydrate, solvate, metabolite, a pharmaceutically acceptable salt or a prodrug. The naphthyridine compound disclosed by the invention has an anti-tumor effect which is obviously superior to the anti-tumor effect of the prior art. And moreover, the naphthyridine compound disclosed by the invention can treat diseases mediated by protein kinase.